HIGHLIGHT
重要成果
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- Fibroblasts Drive Metabolic Reprogramming in Pacemaker Cardiomyocytes
- Circulation Research, Jun 24, 2022
- Methods: Tbx18 (T-box transcription factor 18)-induced PCs and fibroblasts were used for cocultures and e ......
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- Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats
- Nature Biomedical Engineering , Nov 22, 2021
- Pacemaker cells can be differentiated from stem cells or transdifferentiated from quiescent mature cardiac cells via genetic manip ......
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- ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis
- Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166088. , May 01, 2021
- Point mutation in alcohol dehydrogenase 2 (ALDH2), ALDH2*2 results in decreased catalytic enzyme activity and has been ......
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- SVAD: A genetic database curates non-ischemic sudden cardiac death-associated variants
- PLoS One. 2020 Aug 19;15(8):e0237731. , Aug 19, 2020
- Sudden cardiac death (SCD) is an important cause of mortality worldwide. It accounts for approximately half of all deaths from cardiovascula ......
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- Antegrade Conduction Rescues Right Ventricular Pacing-Induced Cardiomyopathy in Complete Heart Block
- Journal of the American College of Cardiology, Apr 09, 2019
- Right ventricular (RV) pacing-induced cardiomyopathy (PICM) occurs in ~30% of patients with RV leads. Here, we evaluate the long-term effect ......
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- The A.I. applications for arrhythmias
- , Jan 01, 2019
- The deep learning model of A.I. successfully identified different patterns of arrhythmias. The accuracy of arrhythmias classification was mo ......
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- Inflammation and the pathogenesis of atrial fibrillation
- Nature Reviews Cardiology, Apr 12, 2015
- Inflammation and fibrotic pathways induced heterogeneous cardiac conduction and arrhythmias including atrial fibrillation and ventricular ta ......
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- Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block.
- Science Translational Medicine, Jul 16, 2014
- The re-expression of the embryonic transcription factor T-box 18 (TBX18) converts cardiomyocytes into pacemaker cells by somatic reprogrammi ......
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