Dr. Hsieh, Patrick Ching-Ho
Distinguished Research Fellow
Division Chief
- 02-27899170 (Lab) (Room No: N417)
- 02-27858594 (Fax)
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Specialty:
- Stem cells and regenerative medicine
- Nanoscience and nanomedicine
- Translational Research
Education and Positions:
M.D. Kaohsiung Medical College
Ph.D. University of Washington, Seattle (Bioengineering)
Highlight Detail
Utility of iPSC-Derived Cells for Disease Modeling, Drug Development, and Cell Therapy
Dr. Hsieh, Patrick Ching-Ho
Cells, Jun 06, 2022
The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the molecular mechanisms of human disease, drug discovery, and regenerative medicine. As such, the use of iPSCs in drug development and validation has shown a sharp increase in the past 15 years. Furthermore, many labs have been successful in reproducing many disease phenotypes, often difficult or impossible to capture, in commonly used cell lines or animal models. However, there still remain limitations such as the variability between iPSC lines as well as their maturity. Here, we aim to discuss the strategies in generating iPSC-derived cardiomyocytes and neurons for use in disease modeling, drug development and their use in cell therapy. View Full-Text
Keywords: induced pluripotent stem cells; cell therapy; cardiomyocytes; neurons