Dr. Roffler, Steve R. 's publons link picture

Dr. Roffler, Steve R.

Distinguished Research Fellow
Division Chief
  • 02-2652-3079 (Lab) (Room No: N233)
  • 02-2782-9142 (Fax)

  1. Antibody Engineering
  2. Directed Molecular Evolution
  3. Prodrugs

Education and Positions:
  • Ph.D. University of California, Berkeley

Highlight Detail

Selective Delivery of PEGylated Compounds to Tumor Cells by anti-PEG Hybrid Antibodies.

Dr. Roffler, Steve R.
Mol Cancer Ther., Apr 07, 2015

Polyethylene glycol (PEG) is attached to many peptides, proteins, liposomes and nanoparticles to reduce their immunogenicity and improve their pharmacokinetic and therapeutic properties. Here we describe hybrid antibodies that can selectively deliver PEGylated medicines, imaging agents or nanomedicines to target cells.