Dr. Yang, Pan-Chyr
Joint Appointment Research Fellow
Academician, Academia Sinica
- 02-27899149 (Lab) (Room No: 511)
- 02-27858594 (Fax)
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Specialty:
- Cell and Molecular Biology
- Cancer genomics
Education and Positions:
M.D., Ph.D. National Taiwan University
Highlight Detail
The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1.
Dr. Yang, Pan-Chyr
J Clin Invest., Aug 01, 2011Metastasis is a predominant cause of death in patients with cancer. It is a complex multistep process that needs to be better understood if we are to develop new approaches to managing tumor metastasis. Tumor cell invasion of the local stroma is suppressed by collapsin response mediator protein-1 (CRMP-1). Recently, we identified a long isoform of CRMP-1 (LCRMP-1), expression of which correlates with cancer cell invasiveness and poor clinical outcome in patients with non-small-cell lung cancer (NSCLC).