The research team led by Dr. Patrick C.H. Hsieh, a distinguished research fellow at the Institute of Biomedical Sciences, Academia Sinica, has published an important study in "Circulation," confirming that the co-transplantation of endothelial cells and cardiomyocytes derived from human induced Pluripotent Stem Cells (hiPSC-ECs and hiPSC-CMs) can successfully regenerate damaged heart tissues and restore heart function in non-human primates.

Heart failure remains a major global cause of death, as the adult heart struggles to self-repair or compensate for lost cardiac muscle cells. The study conducted by Dr. Hsieh's lab demonstrates significant therapeutic effects by simultaneously transplanting differentiated hiPSC-ECs and hiPSC-CMs into the damaged areas of the heart. The co-transplanted animals showed a notable improvement in the graft size and maturity of hiPSC-CMs, while hiPSC-ECs treatment significantly promoted angiogenesis, accompanied by significant recovery in cardiac function. This groundbreaking research not only achieved success in mouse models but also yielded exciting results in non-human primate models.

The title of the study, "Combined Therapy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells for Regenerating Mouse and Non-Human Primate Damaged Hearts," was published in "Circulation" on October 31, 2023, with a high journal impact factor of 39.9, highlighting the exceptional importance of the research.

The collaborative effort of the research team extended across international boundaries, including Dr. Tim Kamp and Dr. Tim Hacker from the University of Wisconsin-Madison in the United States. This groundbreaking study not only represents a significant breakthrough in academia but also opens a door for the treatment of heart diseases, bringing valuable hope for health and life.

本院生醫所謝清河特聘研究員領導的研究團隊在頂尖期刊循環《Circulation》上發表了一項重要的研究成果，證實透過移植人類誘導性多潛能幹細胞(iPSC)衍生的內皮細胞和心肌細胞，可以成功再生恆河猴受損的心臟組織並提升心臟功能，搭建岀下一步通往臨床試驗的橋樑。

心臟衰竭是全球主要的致死原因之一，肇因於人類的心臟缺乏自我修復或組織再生的能力。謝清河實驗室的研究顯示，將iPSC分化的內皮細胞和心肌細胞一同移植至小鼠及恆河猴心臟受損區域，可以顯著提升移植心肌細胞的存活率和成熟度，同時促進血管的新生，以恢復心臟功能，並且抑制心律不整副作用的產生。

研究標題為「結合人類誘導性多潛能幹細胞衍生之心肌細胞和內皮細胞以治療小鼠和非人類靈長類受損心臟」，發表於2023年10月31日的《Circulation》上，期刊影響因子高達39.9，是心血管研究領域影響力最大的學術期刊。

該研究為一跨國合作計畫，主要人員包括中研院生醫所謝清河研究團隊暨美國威斯康辛大學麥迪遜分校的Tim Kamp教授和Tim Hacker博士等。這一突破性的研究不僅在學術上有所建樹，更為心臟疾病治療開啟了一扇希望之門。