Dr. Lee, Yungling Leo

Childhood Asthma Clusters Reveal Neutrophil-Predominant Phenotype with Distinct Gene Expression

Allergy, Mar 25, 2018

Background: Childhood asthma comprises different phenotypes with complex pathophysiology. Different asthma phenotypes evoke various clinical ......


Dr. Lee, Te-Chang

Arsenic trioxide-mediated suppression of miR-182-5p is associated with potent anti-oxidant effects through up-regulation of SESN2

Oncotarget, Mar 23, 2018

Arsenic trioxide (ATO) is a traditional Chinese medicine that can induce oxidative stress for treatment of cancer cells. However, ATO may ge ......


Dr. Huang, Tai-huang

Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction

Scientific Reports, Mar 19, 2018

The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the cons ......


Dr. Yang, Ruey-Bing (Ray)

Inhibition of Endothelial SCUBE2 (Signal Peptide-CUB-EGF Domain-Containing Protein 2), a Novel VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) Coreceptor, Suppresses Tumor Angiogenesis

Arteriosclerosis, Thrombosis, and Vascular Biology, Mar 15, 2018

OBJECTIVE: SCUBE2 (signal peptide-CUB-EGF domain-containing protein 2), expressed on the endothelial cell surface, functions as a novel c ......


Dr. Chang, Ya-Jen

Regulation of type 2 innate lymphoid cell-dependent airway hyperreactivity by butyrate

Journal of Allergy and Clinical Immunology, Mar 06, 2018

BACKGROUND: Allergic asthma is characterized airway hyperreactivity (AHR) and inflammation driven by aberrant TH2 response. Type 2 innate ......


Dr. Su, Chun-Kuei

Nitric Oxide Orchestrates a Power-Law Modulation of Sympathetic Firing Behaviors in Neonatal Rat Spinal Cords

Frontiers in Physiology, Mar 06, 2018

Nitric oxide (NO) is a diffusible gas and has multifarious effects on both pre- and postsynaptic events. As a consequence of complex excitat ......


Dr. Hu, Che-Ming (Jack)

Advances and Opportunities in Nanoparticle- and Nanomaterial-Based Vaccines against Bacterial Infections

Advanced Healthcare Materials, Mar 06, 2018

As the dawn of the postantibiotic era we approach, antibacterial vaccines are becoming increasingly important for managing bacterial infecti ......


Dr. Liao, Fang

The Phosphorylation of CCR6 on Distinct Ser/Thr Residues in the Carboxyl Terminus Differentially Regulates Biological Function

Frontiers in Immunology, Mar 02, 2018

CCR6 is a G protein-coupled receptor (GPCR) that recognizes a single chemokine ligand, CCL20 and is primarily expressed by leukocytes. Upon ......


Dr. Wang, Guey-Shin

Ubiquitination of MBNL1 Is Required for Its Cytoplasmic Localization and Function in Promoting Neurite Outgrowth

Cell Reports, Feb 27, 2018

The Muscleblind-like protein family (MBNL) plays an important role in regulating the transition between differentiation and pluripotency and ......


Dr. Liu, Fu-Tong

Galectin-9 is Critical for Mucosal Adaptive Immunity through the TH17–IgA Axis

American journal of pathology, Feb 16, 2018

Impairment of the intestinal mucosal immunity significantly increases the risk of acute and chronic diseases. Immunoglobulin A (IgA) plays a ......


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