Dr. Lee, Yungling Leo
Childhood Asthma Clusters Reveal Neutrophil-Predominant Phenotype with Distinct Gene Expression
Allergy, Mar 25, 2018
Background: Childhood asthma comprises different phenotypes with complex pathophysiology. Different asthma phenotypes evoke various clinical ......
Dr. Lee, Te-Chang
Arsenic trioxide-mediated suppression of miR-182-5p is associated with potent anti-oxidant effects through up-regulation of SESN2
Oncotarget, Mar 23, 2018
Arsenic trioxide (ATO) is a traditional Chinese medicine that can induce oxidative stress for treatment of cancer cells. However, ATO may ge ......
Dr. Huang, Tai-huang
Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction
Scientific Reports, Mar 19, 2018
The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the cons ......
Dr. Yang, Ruey-Bing (Ray)
Inhibition of Endothelial SCUBE2 (Signal Peptide-CUB-EGF Domain-Containing Protein 2), a Novel VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) Coreceptor, Suppresses Tumor Angiogenesis
Arteriosclerosis, Thrombosis, and Vascular Biology, Mar 15, 2018
SCUBE2 (signal peptide-CUB-EGF domain-containing protein 2), expressed on the endothelial cell surface, functions as a novel c ......
Dr. Chang, Ya-Jen
Regulation of type 2 innate lymphoid cell-dependent airway hyperreactivity by butyrate
Journal of Allergy and Clinical Immunology, Mar 06, 2018
Allergic asthma is characterized airway hyperreactivity (AHR) and inflammation driven by aberrant TH2 response. Type 2 innate ......
Dr. Su, Chun-Kuei
Nitric Oxide Orchestrates a Power-Law Modulation of Sympathetic Firing Behaviors in Neonatal Rat Spinal Cords
Frontiers in Physiology, Mar 06, 2018
Nitric oxide (NO) is a diffusible gas and has multifarious effects on both pre- and postsynaptic events. As a consequence of complex excitat ......
Dr. Hu, Che-Ming (Jack)
Advances and Opportunities in Nanoparticle- and Nanomaterial-Based Vaccines against Bacterial Infections
Advanced Healthcare Materials, Mar 06, 2018
As the dawn of the postantibiotic era we approach, antibacterial vaccines are becoming increasingly important for managing bacterial infecti ......
Dr. Liao, Fang
The Phosphorylation of CCR6 on Distinct Ser/Thr Residues in the Carboxyl Terminus Differentially Regulates Biological Function
Frontiers in Immunology, Mar 02, 2018
CCR6 is a G protein-coupled receptor (GPCR) that recognizes a single chemokine ligand, CCL20 and is primarily expressed by leukocytes. Upon ......
Dr. Wang, Guey-Shin
Ubiquitination of MBNL1 Is Required for Its Cytoplasmic Localization and Function in Promoting Neurite Outgrowth
Cell Reports, Feb 27, 2018
The Muscleblind-like protein family (MBNL) plays an important role in regulating the transition between differentiation and pluripotency and ......
Dr. Liu, Fu-Tong
Galectin-9 is Critical for Mucosal Adaptive Immunity through the TH17–IgA Axis
American journal of pathology, Feb 16, 2018
Impairment of the intestinal mucosal immunity significantly increases the risk of acute and chronic diseases. Immunoglobulin A (IgA) plays a ......