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Structural BiologyResearch Highlights
Dr. Shen, Chen-Yang
npj Genomic Medicine, Jan 19, 2022
A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regu ......
Large-scale genome-wide associations comprising multiple studies have identified hundreds of genetic loci commonly associated with hyperlipidemia-related phenotypes. However, single large cohort remains necessa ...... MORE
Dr. Roffler, Steve R.
Communications Biology, Jan 11, 2022
The interplay between membrane topology and mechanical forces in regulating T cell receptor ac ......
T cells are critically important for host defense against infections. T cell activation is specific because signal initiation requires T cell receptor (TCR) recognition of foreign antigen peptides presented by ...... MORE
Dr. Chern, Yijuang
Movement Disorders, Dec 23, 2021
A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis
Background: Polyglutamine (polyQ) diseases are dominant neurodegenerative diseases caused by an expansion of the polyQ-encoding CAG repeats in the disease-causing gene. The length of the CAG repeats is t ...... MORE
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