癌症研究組從事癌症相關之診斷、治療、及致癌的分子機制研究。目前研發重點為延續前期研究成果,並在癌症發生、轉移的分子機制以及研發癌症治療藥劑方向做更深入探討。主要重點如下:
Mass spectrometry
Proteomics
Mammalian splicing regulatory protein RNA-binding motif protein 4 (RBM4) has an alanine repeat-containing C-terminal domain (CAD) that confe ...
The spliceosomal factor TRAP150 is essential for pre-mRNA splicing in vivo and, when overexpressed, it enhances splicing efficiency. In this ...
The DEAD-box RNA helicase DDX3 is a versatile protein involved in multiple steps of gene expression and various cellular signaling pathways. ...
Heme oxygenase-1 (HO-1) is a heme-degrading enzyme anchored in the endoplasmic reticulum by a carboxyl-terminal transmembrane segment (TMS). ...
Cancer stem cells (CSCs) are a promising target for treating cancer, yet how CSC plasticity is maintained in vivo is unclear and is difficul ...
Human Mps1 (hMps1/TTK) is a mitotic checkpoint kinase responsible for sensing the unattached and tensionless kinetochore. Despite its import ...
Local injection of stem cells or endothelial progenitors directly into the ischaemic tissue remains an option for the management of arterial ...
Early metastasis is one of the major causes of mortality among patient with lung cancer. The process of tumor metastasis involves a cascade ...