2007 成果

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戴榮湘 博士
Activation of Multifarious Transcription of an Adhesion Protein Ap65-1 Gene by a Novel Myb2 Protein in the Protozoan Parasite Trichomonas Vaginalis.
J. Biol. Chem Mar 02, 2007

Multifarious transcription of the adhesion protein ap65-1 gene in the human pathogen, Trichomonas vaginalis, is critically regulated by t ...

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張久瑗 博士
Osteopontin Promotes Integrin Activation through Outside-In and Inside-Out Mechanisms: OPN-CD44V Interaction Enhances Survival in Gastrointestinal Cancer Cells.
Cancer Research Mar 01, 2007

Osteopontin (OPN) and splice variants of CD44 (CD44V) have independently been identified as markers for tumor progression. In this study, ...

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趙麗洋 博士
Systemic Expression of Heme Oxygenase-1 Ameliorates Type 1 Diabetes in Nod.
Diabetes. Feb 15, 2007

Heme oxygenase-1 (HO-1) is an enzyme with potent immunoregulatory capacity. To evaluate the effect of HO-1 on autoimmune diabetes, female ...

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蕭百忍 博士
Partial duplication at AZFc on the Y chromosome is a risk factor for impaired spermatogenesis in Han Chinese in Taiwan.
Human Mutation. Feb 06, 2007

The Azoospermia Factor c (AZFc) region on the Y chromosome long arm is one of the least stable regions in the human genome. It consists a ...

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譚婉玉 博士
Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.
Proc Natl Acad Sci USA. Feb 06, 2007

RNA-binding motif protein 4 (RBM4) plays a regulatory role in alternative splicing of precursor mRNA. We show here that cell stress such ...

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沈志陽 博士
Genetic Variation in the Premature Aging Gene WRN: A Case-Control Study on Breast Cancer usceptibility.
Cancer Epidemiology Biomarkers & Prevention. Feb 01, 2007

The high risk of developing cancer seen in human genetic diseases that resemble accelerated aging provides support for a tumorigenic cont ...

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陳儀莊 博士
Systematic uncovering of multiple pathways underlying the pathology of Huntington's disease by an acid-cleavable isotope-coded affinity tag approach.
Molecular & Cellular Proteomics. Jan 31, 2007

Huntington disease (HD) is an autosomal dominant neurodegenerative disease that results from a CAG (glutamine) trinucleotide expansion in ...

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陳儀莊 博士
Dysregulation of C/EBPa by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease.
Hum Mol Genet. Jan 09, 2007

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingti ...

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沈志陽 博士
Breast Cancer Risk Associated with Genotypic Polymorphism of the Mitotic Checkpoint Genes: a ultigenic Study on Cancer Susceptibility.
Carcinogenesis. Jan 08, 2007

Aneuploidy occurs early during tumorigenesis and may contribute to tumor formation. Tumor cells become aneuploid as a result of aberrant ...

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譚婉玉 博士
Alternative splicing and bioinformatic analysis of human U12-type introns
Nucleic Acids Research. Jan 04, 2007

U12-type introns exist, albeit rarely, in a variety of multicellular organisms. Splicing of U12 intron-containing precursor mRNAs takes p ...

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