2009 成果

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楊泮池 博士
p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug.
Nature Cell Biology May 19, 2009

The tumour suppressor p53 is known to prevent cancer progression by inhibiting proliferation and inducing apoptosis of tumour cells. Slug ...

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王寧 博士
Shear Flow Increases S-nitrosylation of Proteins in Endothelial Cells.
Cardiovascular Research Advance Access May 15, 2009

Aims: Endothelial cells constantly exposed to shear flow increase nitric oxide production via the activation of endothelial nitric oxide ...

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陳儀莊 博士
The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system
Human Molecular Genetics Advance Access May 14, 2009

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingti ...

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林榮信 博士
SLITHER: a web server for generating contiguous conformations of substrate molecules entering into deep active sites of proteins or migrating through channels in membrane transporters.
Nucleic Acids Research, May 11, 2009

Many proteins use a long channel to guide the substrate or ligand molecules into the well-defined active sites for catalytic reactions or ...

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白果能 博士
Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses.
The FASEB Journal May 06, 2009

Toll-like receptors (TLRs) play important roles in the immune responses against invading microorganisms. Development of TLR antagonists i ...

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楊瑞彬 博士
SCUBE2 Suppresses Breast Tumor Cell Proliferation and Confers a Favorable Prognosis in Invasive Breast Cancer.
Cancer Research Apr 15, 2009

Signal peptide-CUB-epidermal growth factor–like domain-containing protein 2 (SCUBE2), originally identified from the endothelium an ...

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謝小燕 博士
TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18.
Mol. Cell. Biol. Mar 30, 2009

Upon prolonged arrest in mitosis, cells undergo adaptation and exit mitosis without cell division. These tetraploid cells are either elim ...

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謝小燕 博士
Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress.
Oncogene Mar 30, 2009

Human checkpoint kinase 1 (CHK1) is an essential kinase required to preserve genome stability, and is activated by DNA replication blocka ...

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羅傅倫 博士
Tumor-Localized Ligation of CD3 and CD28 with Systemic Regulatory T-Cell Depletion Induces Potent Innate and Adaptive Antitumor Responses.
Clinical Cancer Research Mar 24, 2009

Tumor-localized activation of immune cells by membrane-tethered anti-CD3 antibodies (CD3L) is under investigation to treat poorly immunogeni ...

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潘文涵 博士
Fibrinogen Independently Predicts the Development of Ischemic Stroke in a Taiwanese Population. CVDFACTS Study.
Stroke. Mar 12, 2009

Of few prospective studies that have focused on the relationship between fibrinogen and ischemic stroke (IS) in Asian populations, the fi ...

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