The tumour suppressor p53 is known to prevent cancer progression by inhibiting proliferation and inducing apoptosis of tumour cells. Slug ......
Aims: Endothelial cells constantly exposed to shear flow increase nitric oxide production via the activation of endothelial nitric oxide ......
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingti ......
Many proteins use a long channel to guide the substrate or ligand molecules into the well-defined active sites for catalytic reactions or ......
Toll-like receptors (TLRs) play important roles in the immune responses against invading microorganisms. Development of TLR antagonists i ......
Signal peptide-CUB-epidermal growth factor–like domain-containing protein 2 (SCUBE2), originally identified from the endothelium an ......
Upon prolonged arrest in mitosis, cells undergo adaptation and exit mitosis without cell division. These tetraploid cells are either elim ......
Human checkpoint kinase 1 (CHK1) is an essential kinase required to preserve genome stability, and is activated by DNA replication blocka ......
Tumor-localized activation of immune cells by membrane-tethered anti-CD3 antibodies (CD3L) is under investigation to treat poorly immunogeni ......
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