楊泮池 博士p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug.
Nature Cell Biology, May 19, 2009
The tumour suppressor p53 is known to prevent cancer progression by inhibiting proliferation and inducing apoptosis of tumour cells. Slug ......
王寧 博士Shear Flow Increases S-nitrosylation of Proteins in Endothelial Cells.
Cardiovascular Research Advance Access, May 15, 2009
Aims: Endothelial cells constantly exposed to shear flow increase nitric oxide production via the activation of endothelial nitric oxide ......
陳儀莊 博士The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system
Human Molecular Genetics Advance Access, May 14, 2009
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingti ......
林榮信 博士SLITHER: a web server for generating contiguous conformations of substrate molecules entering into deep active sites of proteins or migrating through channels in membrane transporters.
Nucleic Acids Research,, May 11, 2009
Many proteins use a long channel to guide the substrate or ligand molecules into the well-defined active sites for catalytic reactions or ......
白果能 博士Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses.
The FASEB Journal, May 06, 2009
Toll-like receptors (TLRs) play important roles in the immune responses against invading microorganisms. Development of TLR antagonists i ......
楊瑞彬 博士SCUBE2 Suppresses Breast Tumor Cell Proliferation and Confers a Favorable Prognosis in Invasive Breast Cancer.
Cancer Research, Apr 15, 2009
Signal peptide-CUB-epidermal growth factor–like domain-containing protein 2 (SCUBE2), originally identified from the endothelium an ......
謝小燕 博士TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18.
Mol. Cell. Biol., Mar 30, 2009
Upon prolonged arrest in mitosis, cells undergo adaptation and exit mitosis without cell division. These tetraploid cells are either elim ......
謝小燕 博士Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress.
Oncogene, Mar 30, 2009
Human checkpoint kinase 1 (CHK1) is an essential kinase required to preserve genome stability, and is activated by DNA replication blocka ......
羅傅倫 博士Tumor-Localized Ligation of CD3 and CD28 with Systemic Regulatory T-Cell Depletion Induces Potent Innate and Adaptive Antitumor Responses.
Clinical Cancer Research, Mar 24, 2009
Tumor-localized activation of immune cells by membrane-tethered anti-CD3 antibodies (CD3L) is under investigation to treat poorly immunogeni ......
| 記錄 11 到 20 共 27 筆資料 |
