CPEB3 is a sequence-specific RNA-binding protein and represses translation of its target mRNAs in neurons. Here, we have identified a novel ...
Protein palmitoylation has emerged as an important mechanism for regulating protein trafficking, stability, and protein–protein intera ...
Proteins with insignificant sequence and overall structure similarity may still share locally conserved contiguous structural segments; i.e. ...
We employed umbrella sampling molecular dynamics simulations in explicit water to study the binding of the Mg(2+) cofactor to ribonuclease H ...
Engagement of the TCR by antigenic peptides presented by the MHC activates specific T cells to control infections. Recent theoretical consid ...
We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in anothe ...
A variety of stress stimuli, including ischemia-reperfusion (I/R) injury, induce the transcriptional repressor ATF3 in the kidney. The funct ...
The p53 tumor suppressor protein is widely known for its role as a sequence-specific transcription factor that regulates the expression of s ...
To investigate the underlying mechanisms of T2D pathogenesis, we looked for diabetes susceptibility genes that increase the risk of type 2 d ...
TRAP150 has been identified as a subunit of the transcription regulatory complex TRAP/Mediator, and also a component of the spliceosome. The ...
