黃怡萱 博士A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons.
Nucleic Acids Res., Jun 17, 2010
CPEB3 is a sequence-specific RNA-binding protein and represses translation of its target mRNAs in neurons. Here, we have identified a novel ......
陳垣崇 博士Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase.
PLoS Genet., Jun 10, 2010
Protein palmitoylation has emerged as an important mechanism for regulating protein trafficking, stability, and protein–protein intera ......
林小喬 博士A structural-alphabet-based strategy for finding structural motifs across protein families.
Nucleic Acids Res., Jun 04, 2010
Proteins with insignificant sequence and overall structure similarity may still share locally conserved contiguous structural segments; i.e. ......
林小喬 博士Protein/solvent medium effects on Mg(2+)-carboxylate interactions in metalloenzymes.
J Am Chem Soc, May 12, 2010
We employed umbrella sampling molecular dynamics simulations in explicit water to study the binding of the Mg(2+) cofactor to ribonuclease H ......
羅傅倫 博士Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling.
J Immunology, Apr 30, 2010
Engagement of the TCR by antigenic peptides presented by the MHC activates specific T cells to control infections. Recent theoretical consid ......
鄭泰安 博士Genome-wide association study of bipolar I disorder in the Han Chinese population.
Molecular Psychiatry, Apr 13, 2010
We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in anothe ......
楊瑞彬 博士ATF3-Mediated Epigenetic Regulation Protects against Acute Kidney Injury.
JASN, Apr 01, 2010
A variety of stress stimuli, including ischemia-reperfusion (I/R) injury, induce the transcriptional repressor ATF3 in the kidney. The funct ......
謝小燕 博士p53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control.
Oncogene, Mar 01, 2010
The p53 tumor suppressor protein is widely known for its role as a sequence-specific transcription factor that regulates the expression of s ......
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