2014 成果

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林宜玲 博士
Drug Repurposing of Prochlorperazine Against Dengue Virus Infection.
J Infect Dis. Jul 14, 2014

The increasing prevalence of dengue virus (DENV) infection presents serious disease and economic burden in epidemic countries. Despite the c ...

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黃太煌 博士
Structural dynamics of the two-component response regulator RstA in recognition of promoter DNA element.
Nucleic Acids Res. Jul 02, 2014

The RstA/RstB system is a bacterial two-component regulatory system consisting of the membrane sensor, RstB and its cognate response regulat ...

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趙麗洋 博士
Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity.
Oncogene. Jun 16, 2014

Heme oxygenase-1 (HO-1) is a heme-degrading enzyme anchored in the endoplasmic reticulum by a carboxyl-terminal transmembrane segment (TMS). ...

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林宜玲 博士
Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication.
J Virol. Jun 15, 2014

Positive-sense RNA viruses, such as dengue virus (DENV), hijack the intracellular membrane machinery for their own replication. The Rab18 pr ...

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楊泮池 博士
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling.
Nat Commun. May 25, 2014

Cancer stem cells (CSCs) are a promising target for treating cancer, yet how CSC plasticity is maintained in vivo is unclear and is difficul ...

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楊瑞彬 博士
SCUBE3 (Signal Peptide-CUB-EGF Domain-containing Protein 3) Modulates Fibroblast Growth Factor Signaling during Fast Muscle Development.
JBC. May 21, 2014

SCUBE3 (signal peptide CUB-EGF-like domain-containing protein 3) belongs to a newly identified secreted and cell membrane-associated SCUBE f ...

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戴榮湘 博士
Regulation of nuclear translocation of the Myb1 transcription factor by Tv Cyclophilin 1 in the protozoan parasite, Trichomonas vaginalis.
J Biol Chem. May 15, 2014

In Trichomonas vaginalis, a Myb1 protein was previously demonstrated to repress transcription of an iron-inducible ap65-1 gene. In this stud ...

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楊瑞彬 博士
Inhibition of the Plasma SCUBE1, a Novel Platelet Adhesive Protein, Protects Mice Against Thrombosis.
Arterioscler Thromb Vasc Biol. May 15, 2014

Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1), a secreted and surface-exposed glycoprotein on activated platelets, promotes pl ...

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李永凌 博士
β3-Adrenergic receptor gene modifies the association between childhood obesity and asthma.
J Allergy Clin Immunol. Apr 28, 2014

The β3-adrenergic receptor gene (ADRB3) has been reported to be associated with weight gain. 5 The β3-adrenergic receptor would af ...

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陳建璋 博士
Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.
PNAS Apr 28, 2014

The tracheal cartilage rings are important for protecting and maintaining the airway. However, the chondrogenesis of tracheal cartilage is n ...

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