林宜玲博士

Drug Repurposing of Prochlorperazine Against Dengue Virus Infection.

J Infect Dis., Jul 14, 2014

The increasing prevalence of dengue virus (DENV) infection presents serious disease and economic burden in epidemic countries. Despite the c ......

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黃太煌博士

Structural dynamics of the two-component response regulator RstA in recognition of promoter DNA element.

Nucleic Acids Res., Jul 02, 2014

The RstA/RstB system is a bacterial two-component regulatory system consisting of the membrane sensor, RstB and its cognate response regulat ......

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趙麗洋博士

Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity.

Oncogene., Jun 16, 2014

Heme oxygenase-1 (HO-1) is a heme-degrading enzyme anchored in the endoplasmic reticulum by a carboxyl-terminal transmembrane segment (TMS). ......

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林宜玲博士

Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication.

J Virol., Jun 15, 2014

Positive-sense RNA viruses, such as dengue virus (DENV), hijack the intracellular membrane machinery for their own replication. The Rab18 pr ......

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楊泮池博士

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling.

Nat Commun., May 25, 2014

Cancer stem cells (CSCs) are a promising target for treating cancer, yet how CSC plasticity is maintained in vivo is unclear and is difficul ......

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楊瑞彬博士

SCUBE3 (Signal Peptide-CUB-EGF Domain-containing Protein 3) Modulates Fibroblast Growth Factor Signaling during Fast Muscle Development.

JBC., May 21, 2014

SCUBE3 (signal peptide CUB-EGF-like domain-containing protein 3) belongs to a newly identified secreted and cell membrane-associated SCUBE f ......

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戴榮湘博士

Regulation of nuclear translocation of the Myb1 transcription factor by Tv Cyclophilin 1 in the protozoan parasite, Trichomonas vaginalis.

J Biol Chem., May 15, 2014

In Trichomonas vaginalis, a Myb1 protein was previously demonstrated to repress transcription of an iron-inducible ap65-1 gene. In this stud ......

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楊瑞彬博士

Inhibition of the Plasma SCUBE1, a Novel Platelet Adhesive Protein, Protects Mice Against Thrombosis.

Arterioscler Thromb Vasc Biol., May 15, 2014

Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1), a secreted and surface-exposed glycoprotein on activated platelets, promotes pl ......

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李永凌博士

β3-Adrenergic receptor gene modifies the association between childhood obesity and asthma.

J Allergy Clin Immunol., Apr 28, 2014

The β3-adrenergic receptor gene (ADRB3) has been reported to be associated with weight gain. 5 The β3-adrenergic receptor would af ......

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陳建璋博士

Ca_v3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.

PNAS, Apr 28, 2014

The tracheal cartilage rings are important for protecting and maintaining the airway. However, the chondrogenesis of tracheal cartilage is n ......

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