李德章 博士Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives
Eur J Med Chem, Jun 23, 2020
Abstract
A series of 1,2-bis(hydroxymethyl)pyrrolo[1,2-f]phenanthridine derivatives and their alkyl (ethyl and isopropyl) carbamates an ......
周玉山 博士PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility
Cells, Jun 18, 2020
Abstract
Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associat ......
劉扶東 博士Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19)
Journal of Biomedical Science, Jun 04, 2020
On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of ......
楊泮池 博士Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer
Journal of Controlled Release, Jun 01, 2020
Lung cancer is the primary cause of cancer-related death worldwide. 85%–90% of cases are non-small cell lung cancer (NSCLC) which char ......
林小喬 博士How the Local Environment of Functional Sites Regulates Protein Function
Journal of the American Chemical Society, May 19, 2020
Abstract
Proteins form complex biological machineries whose functions in the cell are highly regulated at both the cellular and mol ......
羅傅倫 博士Bispecific Antibody (HER2 × mPEG) Enhances Anti-Cancer Effects by Precise Targeting and Accumulation of mPEGylated Liposomes
Acta Biomaterialia, May 15, 2020
Abstract
Targeted antibodies and methoxy-PEGylated nanocarriers have gradually become a mainstream of cancer therapy. To increase the a ......
沈志陽 博士Tumorigenic and Metastatic Role of CD44−/low/CD24−/low Cells in Luminal Breast Cancer
Cancers, May 14, 2020
Abstract
Cells with high CD44 but low CD24 expression (CD44high/CD24-/low) and high aldehyde dehydrogenase activity (ALDHbr) are widely ......
林宜玲 博士Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice
PLOS Pathogens, May 11, 2020
Abstract
Zika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregna ......
張雅貞 博士Pulmonary IL‐33 orchestrates innate immune cells to mediate RSV‐evoked airway hyperreactivity and eosinophilia
Allergy, Apr 21, 2020
Background
Respiratory syncytial virus (RSV) infection is epidemiologically linked to asthma. During RSV infection, IL‐33 is ......
黃怡萱 博士CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis
Journal of Biomedical Science, Apr 15, 2020
Background
Alveologenesis is the final stage of lung development to form air-exchanging units between alveoli and blood vessels. Genetic ......
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