楊泮池 博士Suppression of Drug-Resistant Non-Small-Cell Lung Cancer with Inhibitors Targeting Minichromosomal Maintenance Protein
Journal of Medicinal Chemistry, Mar 26, 2020
Drug resistance has been a major threat in cancer therapies that necessitates the development of new strategies to overcome this problem. We ......
林小喬 博士Sensitivity of Functional Loop Conformations on Long-Range Electrostatics: Implications for M20 Loop Dynamics in E. coli Dihydrofolate Reductase
Journal of Chemical Theory and Computation, Mar 19, 2020
In E. coli dihydrofolate reductase, unusual conformational motions of a functional M20 loop that interacts with substrate and coenzyme have ......
胡哲銘 博士Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy
Nano Letters, Mar 17, 2020
Many favorable anticancer treatments owe their success to the induction immunogenic cell death (ICD) in cancer cells, which results in the r ......
李家偉 博士Targeting glycosylated PD-1 induces potent anti-tumor immunity
Cancer Research, Mar 10, 2020
Immunotherapies targeting programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) immune checkpoints represent a ......
羅傅倫 博士Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex
ACS Nano, Mar 06, 2020
Anti-polyethylene glycol (PEG) antibodies are present in many healthy individuals as well as in patients receiving polyethylene glycol-funct ......
神奈木玲兒 博士BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells
Cells, Feb 09, 2020
Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 dat ......
林宜玲 博士Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections
Journal of Medicinal Chemistry, Feb 03, 2020
Emerging and resurging mosquito-borne flaviviruses are an important public health challenge. The increased prevalence of dengue virus (DENV) ......
楊泮池 博士Precision Management of Advanced Non–Small Cell Lung Cancer
Annual Review of Medicine, Jan 27, 2020
The rapid evolution of treatment for advanced lung cancer is a story of how scientists have struggled to move from nonselective cytotoxic ch ......
李小媛 博士Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome
Scientific Reports, Jan 23, 2020
The methyl-CpG-binding protein 2 gene, MECP2, is an X chromosome-linked gene encoding the MeCP2 protein, and mutations of MECP2 cause Rett s ......
劉扶東 博士Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells
Journal of Biomedical Science, Jan 15, 2020
Background
Galectin-9 is a β-galactoside-binding protein with two carbohydrate recognition domains. Recent studies have revealed tha ......
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