楊泮池 博士TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma.
EMBO Mol Med., May 15, 2012
Trop-2, a cell surface glycoprotein, contains both extracellular epidermal growth factor-like and thyroglobulin type-1 repeat domains. Low T ......
譚婉玉 博士hnRNP Q regulates Cdc42-mediated neuronal morphogenesis.
Mol Cell Biol., Apr 09, 2012
The RNA-binding protein hnRNP Q has been implicated in neuronal mRNA metabolism. Here, we show that knockdown of hnRNP Q increased neurite c ......
陶秘華 博士Cancer Immunotherapy Using a Membrane-bound Interleukin-12 With B7-1 Transmembrane and Cytoplasmic Domains.
Molecular Therapy, Feb 14, 2012
Interleukin-12 (IL-12) has potent antitumor activity, but its clinical application is limited by severe systemic toxicity, which might be al ......
陳垣崇 博士Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome.
J Allergy Clin Immunol., Feb 07, 2012
The endogenous peptide-loaded HLA-B∗1502 molecule presented CBZ to CTLs without the involvement of intracellular drug metabolism or a ......
李小媛 博士JNK1 Inhibits GluR1 Expression and GluR1-Mediated Calcium Influx through Phosphorylation and Stabilization of Hes-1.
J Neurosci., Feb 01, 2012
The GluR1 subunit of the AMPA receptor plays an important role in excitatory synaptic transmission and synaptic plasticity in the brain, but ......
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