2017 成果

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徐百川 博士
Targeting BDNF in the medial thalamus for the treatment of central poststroke pain in a rodent model
Pain Apr 05, 2017

Approximately 7-10% of patients develop a chronic pain syndrome after stroke. This chronic pain condition is called central poststroke pain ...

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李德章 博士
Promoter hypermethylation of LGALS4 correlates with poor prognosis in patients with urothelial carcinoma
Oncotarget Apr 04, 2017

Galectine-4 (gal-4), encoded by the LGALS4 gene, was recently shown to exhibit a tumor suppressive effect in colorectal carcinoma and pancre ...

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李永凌 博士
Rapid adiposity growth increases risks of new-onset asthma and airway inflammation in children
International Journal of Obesity Apr 04, 2017

Background/objectives: We aim to (1) examine the influence of long-term adiposity status/short-term adiposity changes on asthma with high ...

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譚婉玉 博士
Y14 governs p53 expression and modulates DNA damage sensitivity
Scientific Reports Mar 31, 2017

Y14 is a core component of the exon junction complex (EJC), while it also exerts cellular functions independent of the EJC. Depletion of Y14 ...

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王桂馨 博士
Reduced cytoplasmic MBNL1 is an early event in a brain-specific mouse model of myotonic dystrophy
Human Molecular Genetics Mar 24, 2017

Myotonic dystrophy type 1 (DM1) is caused by an expansion of CTG repeats in the 3’ untranslated region (UTR) of dystrophia myotonia pr ...

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林小喬 博士
How Molecular Size Impacts RMSD Applications in Molecular Dynamics Simulations
Journal of Chemical Theory and Computation Mar 16, 2017

Abstract The root-mean-square deviation (RMSD) is a similarity measure widely used in analysis of macromolecular structures and dynamic ...

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沈志陽 博士
B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers
Scientific Reports Mar 09, 2017

The key signature of cancer genomes is the accumulation of DNA mutations, the most abundant of which is the cytosine-to-thymine (C-to-T) tra ...

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陳垣崇 博士
Knock-in human FGFR3 achondroplasia mutation as a mouse model for human skeletal dysplasia
Scientific Reports Feb 23, 2017

Achondroplasia (ACH), the most common genetic dwarfism in human, is caused by a gain-of function mutation in fibroblast growth factor recept ...

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林小喬 博士
How Native and Alien Metal Cations Bind ATP: Implications for Lithium as a Therapeutic Agent
Scientific Reports Feb 14, 2017

Adenosine triphosphate (ATP), the major energy currency of the cell, exists in solution mostly as ATP-Mg. Recent experiments suggest that Mg ...

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李小媛 博士
Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer’s disease
Cell Death and Differentiation Feb 10, 2017

Amyloid-β (Aβ) produces neurotoxicity in the brain and causes neuronal death, but the endogenous defense mechanism that is activat ...

Years