羅傅倫 博士The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering
Frontiers in Immunology, Jul 10, 2017
T lymphocytes are important mediators of adoptive immunity but the mechanism of T cell receptor (TCR) triggering remains uncertain. The inte ......
嚴仲陽 博士Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction
Scientific Reports, Jul 04, 2017
JAK2 activation is crucial for cytokine receptor signal transduction and leukemogenesis. However, the underlying processes that lead to full ......
潘文涵 博士Dietary Pattern Associated with Frailty: Results from Nutrition and Health Survey in Taiwan
Journal of the American Geriatrics Society, Jun 12, 2017
Objectives
To investigate whether dietary patterns are associated with frailty phenotypes in an elderly Taiwanese population.
De ......
羅傅倫 博士Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy
Nature Communications, Jun 08, 2017
Triple-negative breast cancer (TNBC) lacks effective treatment options due to the absence of traditional therapeutic targets. The epidermal ......
陳士隆 博士Hepatitis C virus subverts human choline kinase-α to bridge PI4KIIIα and NS5A and upregulates PI4KIIIα activation, thereby promoting the translocation of the ternary complex to the ER for viral replication
Journal of Virology, May 31, 2017
In this study, we elucidated the mechanism by which human choline kinase-α (hCKα) interacts with nonstructural protein (NS)5A an ......
陳垣崇 博士Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver
Scientific Reports, May 19, 2017
Palmitoyltransferase (PAT) catalyses protein S-palmitoylation which adds 16-carbon palmitate to specific cysteines and contributes to variou ......
陳儀莊 博士Energy Homeostasis and Abnormal RNA Metabolism in Amyotrophic Lateral Sclerosis
Frontiers in Cellular Neuroscience, May 04, 2017
Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease that is clinically characterized by progressive muscle wea ......
林小喬 博士Modeled structural basis for the recognition of α2-3-sialyllactose by soluble Klotho
The FASEB Journal, Apr 25, 2017
Soluble Klotho (sKlotho) is the shed ectodomain of antiaging membrane Klotho that contains 2 extracellular domains KL1 and KL2, each of whic ......
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