2017 成果

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謝清河 博士
Subcellular Localization of Survivin Determines Its Function in Cardiomyocytes
Theranostics Oct 13, 2017

Rationale: Reducing cardiomyocyte death and enhancing their proliferation after myocardial infarction is perhaps the single largest challeng ...

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陳建璋 博士
Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus
Nature Communications Oct 10, 2017

Myocardial infarction is the leading cause of death worldwide. Restoration of blood flow rescues myocardium but also causes ischemia-reperfu ...

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楊瑞彬 博士
FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation
Breast Cancer Research Oct 05, 2017

Background Core fucosylation (addition of fucose in α-1,6-linkage to core N-acetylglucosamine of N-glycans) catalyzed by fuco ...

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楊瑞彬 博士
Guanylyl cyclase‐G is an alarm pheromone receptor in mice
EMBO Journal Sep 28, 2017

Many animals respond to threats by releasing alarm pheromones (APs) that warn conspecifics. In mice, detection of the AP 2‐sec‐butyl‐4,5‐dih ...

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謝清河 博士
Fenugreek Compound (N55) Lowers Plasma Glucose through the Enhancement of Response of Physiological Glucagon-like peptide-1
Scientific Reports Sep 25, 2017

Glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) analogues are approved for treating type 2 diabetes, but are known to activate GLP-1R sign ...

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林天南 博士
Clinacanthus nutans Mitigates Neuronal Apoptosis and Ischemic Brain Damage Through Augmenting the C/EBPβ-Driven PPAR-γ Transcription
Molecular Neurobiology Sep 23, 2017

Clinacanthus nutans Lindau (C. nutans) is a traditional herbal medicine widely used in Asian countries for treating a number of remedies inc ...

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鄔哲源 博士
A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol
Nature Communications Sep 12, 2017

Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. However, some health ...

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周玉山 博士
Pyrimidine metabolic rate limiting enzymes in poorly-differentiated hepatocellular carcinoma are signature genes of cancer stemness and associated with poor prognosis
Oncotarget Sep 08, 2017

Cellular metabolism of cancer cell is generally recognized to provide energy for facilitating tumor growth, but little is known about the ab ...

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潘文涵 博士
Intake of potassium- and magnesium-enriched salt improves functional outcome after stroke: a randomized, multicenter, double-blind controlled trial
The American Journal of Clinical Nutrition Sep 06, 2017

Background: Stroke is one of the leading causes of mortality and neurologic deficits. Management measures to improve neurologic outcomes are ...

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王桂馨 博士
CELF1 Mediates Connexin 43 mRNA Degradation in Dilated Cardiomyopathy
Circulation Research Sep 05, 2017

Rationale: Downregulation of connexin 43 (Cx43), the major cardiac gap junction protein, is often associated with arrhythmia, dilated cardio ...

Years