2022 成果

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陶秘華 博士
A receptor-binding domain-based nanoparticle vaccine elicits durable neutralizing antibody responses against SARS-CoV-2 and variants of concern
Emerging Microbes & Infections Nov 17, 2022

      Numerous vaccines have been developed to address the current COVID-19 pandemic, but safety, cross-neutralizing ...

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陳世淯 博士
Spatial multi-omics analyses of the tumor immune microenvironment
Journal of Biomedical Science Nov 14, 2022

In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-immune microenvironment at the genomic, transcript ...

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范盛娟 博士
Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes
Communications Biology Nov 03, 2022

      To explore the complex genetic architecture of common diseases and traits, we conducted comprehensive PheWAS o ...

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李玲慧 博士
Enrichment of Prevotella intermedia in human colorectal cancer and its additive effects with Fusobacterium nucleatum on the malignant transformation of colorectal adenomas
Journal of Biomedical Science Oct 27, 2022

      Methods: Microbiota composition was determined through 16S rRNA V3-V4 amplicon sequencing of autologous a ...

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謝清河 博士
Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice
Theranostics Oct 17, 2022

        Background: The gut microbiota plays a vital role in maintaining tissue homeostasis and regulat ...

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謝清河 博士
Depletion of gut microbiota improves the therapeutic efficacy of cancer nanomedicine
Theranostics Oct 17, 2022

        Rationale: Gut microbiota plays a crucial role in cancer development and treatment. Studies sho ...

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李家偉 博士
Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis
American Journal of Cancer Research Oct 15, 2022

      N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor ant ...

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李永凌 博士
Mediators linking obesity to childhood asthma
Pediatric Allergy and Immunology Oct 01, 2022

      Background: Obesity and asthma are highly associated, but the mechanisms underlying the association remai ...

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林文昌 博士
TEx-MST: tissue expression profiles of MANE select transcripts
Database(Oxford) Sep 28, 2022

      Recently, a new reference transcript dataset [Matched Annotation from the NCBI and EMBL-EBI (MANE) select] was ...

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潘文涵 博士
Positive or U-Shaped Association of Elevated Hemoglobin Concentration Levels with Metabolic Syndrome and Metabolic Components: Findings from Taiwan Biobank and UK Biobank
Nutrients Sep 27, 2022

      Iron overnutrition has been implicated with a higher risk of developing metabolic and cardiovascular diseases, ...

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