張久瑗 博士

Patient-Derived Organoid Serves as a Platform for Personalized Chemotherapy in Advanced Colorectal Cancer Patients

Frontiers in Oncology, Jun 01, 2022

      Background: Addition of oxaliplatin to adjuvant 5-FU has significantly improved the disease-free survival ......

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林小喬 博士

From quantum-derived principles underlying cysteine reactivity to combating the COVID-19 pandemic

Wiley Interdisciplinary Reviews-Computational Molecular Science, May 25, 2022

      The COVID‐19 pandemic poses a challenge in coming up with quick and effective means to counter its cause, the ......

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王桂馨 博士

Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration

Journal of Neuroscience, May 23, 2022

    Increasing loss of structure and function of neurons and decline in cognitive function is commonly seen during the progr ......

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陳建璋 博士

The Tarantula Toxin ω-Avsp1a Specifically Inhibits Human CaV3.1 and CaV3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor

Biomedicines, May 04, 2022

      Inhibition of T-type calcium channels (CaV3) prevents development of diseases related to cardiovascular and ne ......

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陳志成 博士

Force From Filaments: The Role of the Cytoskeleton and Extracellular Matrix in the Gating of Mechanosensitive Channels

Frontiers in cell and developmental biology, May 02, 2022

The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion channels that transduce mechanical stimuli with hig ......

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陳志成 博士

A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain

PAIN, May 01, 2022

    Prolotherapy is widely used in pain control and tissue repair in pain medicine. The classical mode is injection with hyp ......

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林文昌 博士

Dominant transcript expression profiles of human protein-coding genes interrogated with GTEx dataset

Scientific Reports, Apr 28, 2022

      The discovery and quantification of mRNA transcripts using short-read next-generation sequencing (NGS) data is ......

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周玉山 博士

Prognostic comparative genes predict targets for sorafenib combination therapies in hepatocellular carcinoma

Comput Struct Biotechnol J, Apr 20, 2022

      With the increasing incidence and mortality of human hepatocellular carcinoma (HCC) worldwide, revealing innov ......

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牟昀 博士

Development of a TNF-α-mediated Trojan Horse for Bacteria-based Cancer Therapy

Molecular Therapy, Apr 19, 2022

      TNF-α is up-regulated in a chronic inflammatory environment, including tumors, and has been recognized a ......

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陳金榜 博士

Structural insights into DNA binding domain of vancomycin-resistance-associated response regulator in complex with its promoter DNA from Staphylococcus aureus

Protein Science, Apr 09, 2022

      In Staphylococcus aureus, vancomycin-resistance-associated response regulator (VraR) is a part of the Vra ......

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