2022 成果

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張雅貞 博士
The ketone body β-hydroxybutyrate mitigates ILC2-driven airway inflammation by regulating mast cell function
Cell Reports Sep 27, 2022

Ketone bodies are increasingly understood to have regulatory effects on immune cell function, with β-hydroxybutyrate (BHB) exerting a p ...

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謝清河 博士
The gut microbiota regulates acute foreign body reaction and tissue repair after biomaterial implantation
Biomaterials Sep 19, 2022

    We hypothesized that the host microbiome may influence foreign body responses following biomaterial implantation. To tes ...

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楊泮池 博士
Stage Shift Improves Lung Cancer Survival: Real-World Evidence
Journal of Thoracic Oncology Sep 18, 2022

      Introduction Lung cancer is the global leading cause of cancer death. Taiwan initiated several health polic ...

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楊鎧鍵 博士
The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications
Journal of Biomedical Science Sep 02, 2022

      Fibrosis-related disorders account for an enormous burden of disease-associated morbidity and mortality worldw ...

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楊瑞彬 博士
Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia
Haematologica Aug 25, 2022

      A hallmark of mixed lineage leukemia gene-rearranged (MLL-r) acute myeloid leukemia (AML) that offers an oppor ...

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陳儀莊 博士
TRAX Provides Neuroprotection for Huntington's Disease Via Modulating a Novel Subset of MicroRNAs
Movement Disorders Aug 23, 2022

      Background: Huntington's disease (HD) is a neurodegenerative disease caused by CAG-repeat expansions (>36 ...

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潘文涵 博士
Common and Ethnic-Specific Genetic Determinants of Hemoglobin Concentration between Taiwanese Han Chinese and European Whites: Findings from Comparative Two-Stage Genome-Wide Association Studies
Journal of Nutritional Biochemistry Aug 11, 2022

      Human iron nutrition is a result of interplays between genetic and environmental factors. However, there has b ...

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謝小燕 博士
JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
Cell Death & Disease Jul 18, 2022

      Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the s ...

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林榮信 博士
A Curvilinear-Path Umbrella Sampling Approach to Characterizing the Interactions Between Rapamycin and Three FKBP12 Variants
Frontiers in Molecular Biosciences Jul 08, 2022

      Rapamycin is an immunosuppressant macrolide that exhibits anti-proliferative properties through inhibiting the ...

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陶秘華 博士
A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants
Journal of Biomedical Science Jul 07, 2022

      Background: With the continuous emergence of new SARS-CoV-2 variants that feature increased transmissio ...

Years