2022 Highlights

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Dr. Chen , Joanne Jeou-Yuan
Patient-Derived Organoid Serves as a Platform for Personalized Chemotherapy in Advanced Colorectal Cancer Patients
Frontiers in Oncology Jun 01, 2022

      Background: Addition of oxaliplatin to adjuvant 5-FU has significantly improved the disease-free survival ...

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Dr. Lim , Carmay
From quantum-derived principles underlying cysteine reactivity to combating the COVID-19 pandemic
Wiley Interdisciplinary Reviews-Computational Molecular Science May 25, 2022

      The COVID‐19 pandemic poses a challenge in coming up with quick and effective means to counter its cause, the ...

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Dr. Wang , Guey-Shin
Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration
Journal of Neuroscience May 23, 2022

    Increasing loss of structure and function of neurons and decline in cognitive function is commonly seen during the progr ...

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Dr. Chen , Chien-Chang
The Tarantula Toxin ω-Avsp1a Specifically Inhibits Human CaV3.1 and CaV3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor
Biomedicines May 04, 2022

      Inhibition of T-type calcium channels (CaV3) prevents development of diseases related to cardiovascular and ne ...

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Dr. Chen , Chih-Cheng
Force From Filaments: The Role of the Cytoskeleton and Extracellular Matrix in the Gating of Mechanosensitive Channels
Frontiers in cell and developmental biology May 02, 2022

The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion channels that transduce mechanical stimuli with hig ...

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Dr. Chen , Chih-Cheng
A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain
PAIN May 01, 2022

    Prolotherapy is widely used in pain control and tissue repair in pain medicine. The classical mode is injection with hyp ...

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Dr. Lin , Wen-chang
Dominant transcript expression profiles of human protein-coding genes interrogated with GTEx dataset
Scientific Reports Apr 28, 2022

      The discovery and quantification of mRNA transcripts using short-read next-generation sequencing (NGS) data is ...

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Dr. Jou , Yuh-Shan
Prognostic comparative genes predict targets for sorafenib combination therapies in hepatocellular carcinoma
Comput Struct Biotechnol J Apr 20, 2022

      With the increasing incidence and mortality of human hepatocellular carcinoma (HCC) worldwide, revealing innov ...

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Dr. Mou , Yun
Development of a TNF-α-mediated Trojan Horse for Bacteria-based Cancer Therapy
Molecular Therapy Apr 19, 2022

      TNF-α is up-regulated in a chronic inflammatory environment, including tumors, and has been recognized a ...

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Dr. Chen , Chinpan
Structural insights into DNA binding domain of vancomycin-resistance-associated response regulator in complex with its promoter DNA from Staphylococcus aureus
Protein Science Apr 09, 2022

      In Staphylococcus aureus, vancomycin-resistance-associated response regulator (VraR) is a part of the Vra ...

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