Dr. Chen, Chih-Cheng

A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain

PAIN, May 01, 2022

    Prolotherapy is widely used in pain control and tissue repair in pain medicine. The classical mode is injection with hyp ......

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Dr. Lin, Wen-chang

Dominant transcript expression profiles of human protein-coding genes interrogated with GTEx dataset

Scientific Reports, Apr 28, 2022

      The discovery and quantification of mRNA transcripts using short-read next-generation sequencing (NGS) data is ......

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Dr. Jou, Yuh-Shan

Prognostic comparative genes predict targets for sorafenib combination therapies in hepatocellular carcinoma

Comput Struct Biotechnol J, Apr 20, 2022

      With the increasing incidence and mortality of human hepatocellular carcinoma (HCC) worldwide, revealing innov ......

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Dr. Mou, Yun

Development of a TNF-α-mediated Trojan Horse for Bacteria-based Cancer Therapy

Molecular Therapy, Apr 19, 2022

      TNF-α is up-regulated in a chronic inflammatory environment, including tumors, and has been recognized a ......

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Dr. Chen, Chinpan

Structural insights into DNA binding domain of vancomycin-resistance-associated response regulator in complex with its promoter DNA from Staphylococcus aureus

Protein Science, Apr 09, 2022

      In Staphylococcus aureus, vancomycin-resistance-associated response regulator (VraR) is a part of the Vra ......

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Dr. Yang, Shi-Bing

Carbamazepine promotes surface expression of mutant Kir6.2-A28V ATP-sensitive potassium channels by modulating Golgi retention and autophagy

Journal of Biological Chemistry, Apr 06, 2022

      Pancreatic β-cells express ATP-sensitive potassium (KATP) channels, consisting of octamer complexes conta ......

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Dr. Hsieh, Patrick Ching-Ho

Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons

Cell Reports, Apr 05, 2022

      In this study, we establish a population-based human induced pluripotent stem cell (hiPSC) drug screening plat ......

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Dr. Tang, Tang K.

A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis

Journal of Biomedical Science, Apr 01, 2022

    Background Metastasis is the major cause of morbidity and mortality in cancer that involves in multiple steps includi ......

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Dr. Mou, Yun

Fragment-Directed Random Mutagenesis by the Reverse Kunkel Method

ACS Synthetic Biology, Mar 24, 2022

      Two fundamentally different approaches are routinely used for protein engineering: user-defined mutagenesis an ......

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Dr. Yang, Ruey-Bing (Ray)

Quantitative glycoproteomics analysis identifies novel FUT8 targets and signaling networks critical for breast cancer cell invasiveness

Breast Cancer Research, Mar 18, 2022

      Background We recently showed that fucosyltransferase 8 (FUT8)-mediated core fucosylation of transforming g ......

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