2013 Highlights

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Dr. Chen , Chien-Chang
Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy.
Mol Cell Proteomics. Jul 23, 2013

Pressure-overload stress to the heart causes pathological cardiac hypertrophy, which increases the risk of cardiac morbidity and mortality. ...

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Dr. Chen , Chinpan
Structural Basis of a Physical Blockage Mechanism for the Interaction of Response Regulator PmrA with Connector Protein PmrD from Klebsiella Pneumoniae.
J Biol Chem. Jul 16, 2013

In bacteria, the two-component system (TCS) is the most prevalent for sensing and transducing environmental signals into the cell. The PmrA- ...

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Dr. Tang , Tang K.
CEP120 interacts with CPAP and positively regulates centriole elongation.
JCB. Jul 15, 2013

Centriole duplication begins with the formation of a single procentriole next to a preexisting centriole. CPAP (centrosomal protein 4.1&ndas ...

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Dr. Shih , Hsiu-Ming
HIC1 interacts with and modulates the activity of STAT3.
Cell Cycle. Jun 21, 2013

Abstract: HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene, expression of which is frequently suppressed in human cancers. Very ...

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Dr. Shih , Chiaho
Identification of a Novel Antimicrobial Peptide from Human Hepatitis B Virus Core Protein Arginine-Rich Domain (ARD).
PLOS Pathogens. Jun 13, 2013

The rise of multidrug-resistant (MDR) pathogens causes an increasing challenge to public health. Antimicrobial peptides are considered a pos ...

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Dr. Chang , Chen
Visualization of rodent brain tumor angiogenesis and effects of antiangiogenic treatment using 3D ΔR2-μMRA.
Angiogenesis. Jun 05, 2013

Understanding of structural and functional characteristics of the vascular microenvironment in gliomas and the impact of antiangiogenic trea ...

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Dr. Chang , Chen
Hyperglycemia Exacerbates Intracerebral Hemorrhage via the Downregulation of Aquaporin-4.
Stroke. Jun 01, 2013

Intracerebral hemorrhage (ICH) is associated with high mortality and neurological deficits, and concurrent hyperglycemia usually worsens cli ...

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Dr. Chern , Yijuang
Lack of Type VI Adenylyl Cyclase (AC6) Leads to Abnormal Sympathetic Tone in Neonatal Mice.
Exp Neurol. May 28, 2013

Visceral functions are regulated by a basal sympathetic nerve discharge (SND), also known as 'sympathetic tone'. We demonstrate here ...

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Dr. Hsieh , Patrick Ching-Ho
Functionalized Nanoparticles Provide Early Cardioprotection after Acute Myocardial Infarction.
J Control Release May 09, 2013

Recent developments in nanotechnology have created considerable potential toward diagnosis and cancer therapy. In contrast, the use of nanot ...

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Dr. Lim , Carmay
Differential Role of the Protein Matrix on the Binding of a Catalytic Aspartate to Mg2+ vs Ca2+: Application to Ribonuclease H.
J Am Chem Soc. Apr 23, 2013

Divalent metal cations are essential cofactors for many enzyme functions. Although Mg2+ is the native cofactor in many enzymes such as ribon ...

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