2013 Highlights

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Dr. Hwang , Ming-Jing
LISE: a server using ligand-interacting and site-enriched protein triangles for prediction of ligand-binding sites.
Nucl. Acids Res. Apr 22, 2013

LISE is a web server for a novel method for predicting small molecule binding sites on proteins. It differs from a number of servers current ...

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Dr. Shieh , Sheau-Yann
Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1.
PNAS Mar 26, 2013

B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG/ Transducer of ErbB2 gene family and is induced by genotoxic str ...

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Dr. Tang , Tang K.
Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly.
EMBO J. Mar 19, 2013

Centrioles are cylindrical structures that are usually composed of nine triplets of microtubules (MTs) organized around a cartwheel-shaped s ...

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Dr. Yang , Pan-Chyr
Extracellular delivery of modified oligonucleotide and superparamagnetic iron oxide nanoparticles from a degradable hydrogel triggered by tumor acidosis.
Biomaterials. Mar 08, 2013

Chemically modified antisense RNA oligonucleotides (antagomir) offer promise for cancer therapies but suffer from poor therapeutic effect af ...

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Dr. Jou , Yuh-Shan
Overexpressed-eIF3I interacted and activated oncogenic Akt1 is a theranostic target in human hepatocellular carcinoma.
Hepatology. Mar 04, 2013

Eukaryotic translation initiation factor 3 subunit I (eIF3I) with transforming capability is often overexpressed in human hepatocellular car ...

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Dr. Yang , Ruey-Bing (Ray)
Zebrafish scube1 (Signal Peptide-CUB (Complement Protein C1r/C1s, Uegf, and Bmp1)-EGF (Epidermal Growth Factor) Domain-containing Protein 1) Is Involved in Primitive Hematopoiesis.
J Biol Chem. Feb 15, 2013

scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF domain-containing protein 1), the founding member of a novel sec ...

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Dr. Shih , Hsiu-Ming
Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.
EMBO J. Feb 08, 2013

While numerous small ubiquitin-like modifier (SUMO) conjugated substrates have been identified, very little is known about the cellular sign ...

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Dr. Chau , Lee-Young
Activator Protein-2α Mediates Carbon Monoxide-Induced Stromal Cell-Derived Factor-1α Expression and Vascularization in Ischemic Heart.
Arterioscler Thromb Vasc Biol. Feb 07, 2013

Increased cardiac stromal cell-derived factor-1α (SDF-1α) expression promotes neovascularization and myocardial repair after isc ...

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Dr. Lee , Eminy H.Y.
NMDA receptor signaling mediates the expression of protein inhibitor of activated STAT1 (PIAS1) in rat hippocampus.
Neuropharmacology Feb 01, 2013

Protein inhibitor of activated STAT1 (PIAS1) was shown to play an important role in inflammation and innate immune response, but how PIAS1 i ...

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Dr. Chern , Yijuang
A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease.
Hum Mol Genet. Jan 30, 2013

Huntington's disease (HD) is an autosomal disease caused by a CAG repeat expansion in the huntingtin (HTT) gene. The resultant mutant HTT pr ...

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