Dr. Chen, Chien-Chang Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy.
Mol Cell Proteomics., Jul 23, 2013Pressure-overload stress to the heart causes pathological cardiac hypertrophy, which increases the risk of cardiac morbidity and mortality. ......
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Dr. Chen, Chinpan Structural Basis of a Physical Blockage Mechanism for the Interaction of Response Regulator PmrA with Connector Protein PmrD from Klebsiella Pneumoniae.
J Biol Chem., Jul 16, 2013In bacteria, the two-component system (TCS) is the most prevalent for sensing and transducing environmental signals into the cell. The PmrA- ......
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Dr. Tang, Tang K. CEP120 interacts with CPAP and positively regulates centriole elongation.
JCB., Jul 15, 2013Centriole duplication begins with the formation of a single procentriole next to a preexisting centriole. CPAP (centrosomal protein 4.1&ndas ......
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Dr. Shih, Hsiu-Ming HIC1 interacts with and modulates the activity of STAT3.
Cell Cycle., Jun 21, 2013Abstract: HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene, expression of which is frequently suppressed in human cancers. Very ......
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Dr. Shih, Chiaho Identification of a Novel Antimicrobial Peptide from Human Hepatitis B Virus Core Protein Arginine-Rich Domain (ARD).
PLOS Pathogens., Jun 13, 2013The rise of multidrug-resistant (MDR) pathogens causes an increasing challenge to public health. Antimicrobial peptides are considered a pos ......
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Dr. Chang, Chen Visualization of rodent brain tumor angiogenesis and effects of antiangiogenic treatment using 3D ΔR2-μMRA.
Angiogenesis., Jun 05, 2013Understanding of structural and functional characteristics of the vascular microenvironment in gliomas and the impact of antiangiogenic trea ......
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Dr. Chang, Chen Hyperglycemia Exacerbates Intracerebral Hemorrhage via the Downregulation of Aquaporin-4.
Stroke., Jun 01, 2013Intracerebral hemorrhage (ICH) is associated with high mortality and neurological deficits, and concurrent hyperglycemia usually worsens cli ......
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Dr. Chern, Yijuang Lack of Type VI Adenylyl Cyclase (AC6) Leads to Abnormal Sympathetic Tone in Neonatal Mice.
Exp Neurol., May 28, 2013Visceral functions are regulated by a basal sympathetic nerve discharge (SND), also known as 'sympathetic tone'. We demonstrate here ......
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Dr. Hsieh, Patrick Ching-Ho Functionalized Nanoparticles Provide Early Cardioprotection after Acute Myocardial Infarction.
J Control Release, May 09, 2013Recent developments in nanotechnology have created considerable potential toward diagnosis and cancer therapy. In contrast, the use of nanot ......
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Dr. Lim, Carmay Differential Role of the Protein Matrix on the Binding of a Catalytic Aspartate to Mg2+ vs Ca2+: Application to Ribonuclease H.
J Am Chem Soc., Apr 23, 2013Divalent metal cations are essential cofactors for many enzyme functions. Although Mg2+ is the native cofactor in many enzymes such as ribon ......
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