2013 Highlights

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Dr. Shyue , Song-Kun
Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.
J Biol Chem. Oct 02, 2013

Caveolin-1 (Cav-1) interacts with and mediates protein trafficking and various cellular functions. Derlin-1 is a candidate for the retrotran ...

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Dr. Lim , Carmay
Importance of Metal Hydration on the Selectivity of Mg2+ vs. Ca2+ in Magnesium Ion Channels.
J Am Chem Soc. Oct 02, 2013

Magnesium ion channels and transporters regulate the cellular concentrations of Mg2+, which must be tightly controlled as imbalances have be ...

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Dr. Hsieh , Patrick Ching-Ho
Comprehensive characterizations of nanoparticle biodistribution following systemic injection in mice.
Nanoscale. Sep 26, 2013

Various nanoparticle (NP) properties such as shape and surface charge have been studied in an attempt to enhance the efficacy of NPs in biom ...

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Dr. Shen , Chen-Yang
A novel estrogen receptor-microRNA 190a-PAR-1-pathway regulates breast cancer progression, a finding initially suggested by genome-wide analysis of loci associated with lymph-node metastasis.
Hum Mol Genet. Sep 22, 2013

To identify microRNAs that are important in regulating breast cancer progression, the present study used data for the 199 961 single-nucleot ...

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Dr. Lim , Carmay
Competition among Metal Ions for Protein Binding Sites: Determinants of Metal Ion Selectivity in Proteins.
Chem Rev. Sep 16, 2013

Metal cations are indispensable components of the cellular machinery and are involved in numerous essential tasks ranging from nucleic acid ...

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Dr. Lim , Carmay
Identification of Labile Zn Sites in Drug-Target Proteins.
J Am Chem Soc. Sep 11, 2013

Labile Zn fingers (Zfs) in proteins contain Zn-bound thiolates that can react with electrophilic agents, causing Zn2+ ejection and protein u ...

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Dr. Yen , Pauline H.
DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts
Nucl. Acids Res. Aug 21, 2013

Deleted in Azoospermia Associated Protein 1 (DAZAP1) is a ubiquitous heterogeneous nuclear ribonucleoprotein (hnRNP) that is expressed abund ...

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Dr. Lin , Yi-Ling
Ubiquitin-Specific Protease 13 Regulates IFN Signaling by Stabilizing STAT1.
J Immunol. Aug 12, 2013

The IFN immune system comprises type I, II, and III IFNs, signals through the JAK-STAT pathway, and plays central roles in host defense agai ...

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Dr. Chen , Chien-Chang
Early Growth Response 1 is an Early Signal Inducing Cav3.2 T-type Calcium Channels During Cardiac Hypertrophy.
Cardiovasc Res. Aug 08, 2013

The Cav3.2 T-channel plays a pivotal role in inducing calcineurin/nuclear factor of activated T cell (NFAT) signaling during cardiac hypertr ...

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Dr. Liao , Fang
Melanoma Differentiation–Associated Gene 5 Senses Hepatitis B Virus and Activates Innate Immune Signaling to Suppress Virus Replication.
J Immunol. Aug 07, 2013

Retinoic acid–inducible gene-I (RIG-I) and melanoma differentiation–associated gene 5 (MDA5) belong to the RIG-I–like rece ...

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